Scientist, Molecular Biologist in Seville

CITRE®, the Celgene Institute for Translational Research Europe is providing Celgene with the platform to build an International presence in Seville, Spain.

This is a significant investment by Celgene in the continued development of cutting edge technology in Europe. It will represent Celgene's first centre outside of United States exclusively dedicated to R&D.

The centre will grow over the next three years to 30 international scientists intent on bridging the gap between basic science and clinical research, combining the talent and expertise from within the Biopharmaceutical industry and academia.
The Celgene Institute of Translational Research Europe, occupies more than 1000 square meters divided into three floors within a building at the Cartuja93 Science and Technology Park in Seville - http://pctcartuja.es/Home/tabid/77/language/en-GB/Default.aspx

CITRE will be the focal point for advanced biomedical research including regenerative medicine, personalized medicine and cellular therapies.
CITRE will consist of five departments:-

• Tumor biobanking,
• Bioinformatics,
• Placental stem cells,
• Epigenetics
• Cell signaling.

These functional departments will be further supported by five services:-

• Cell culture
• Cytometry
• Electronic microscopy
• Genomics and
• Proteomics

Located in Seville, Spain, CITRE reflects a shared vision between Celgene and the public sectors of Spain and Europe to provide a bridge between the discoveries of basic research and their application in addressing the needs of modern medicine.
Celgene invested approximately $800 million in research, traditionally investing about 30% of the company revenues in R&D.

Background to the Role

The area of translational development at Celgene is to provide a team that is fully integrated both with our discovery efforts and clinical development. To enable this, Translational Development will engage with discovery project teams to support target selection and disease area strategies, provide leadership for early clinical programmes from CD nomination to proof of principle (i.e., Phase 2A) studies. In order to facilitate this, Translational Development will be integrated into Early Development Teams that will cost effectively and rapidly move the portfolio through early safety, efficacy and signal searching studies and ultimately hand over provide a robust roadmap for registration to the late development or Brand Teams. The Translational Development group is responsible for working with discovery to develop target validation approaches, define appropriate disease models for clinical studies, early engagement with discovery and early development team for biomarker maker development, defining patient selection strategies, and clinical pharmacology to define starting doses and schedules for dose escalation in Phase 1 studies. In addition rational design of combination of novel molecules which challenge the current treatment paradigms will be encouraged. There is a close working relationship with toxicology

As part of Celgene’s commitment to scientific excellence and research in Europe, we have established the Centre for Translational Research in Europe (CITRE) in Sevilla. The aim of this centre is to be the European Hub for our BioBanking, Bioinformatics and Early Phase Clinical Trials. In addition we are aiming to develop facilities for stem progenitor cell research. These will complement our early research facilities in San Diego, San Francisco and Summit NJ. We are seeking to help gifted scientific expert with a proven track record in academia or industry to create this unique installation and deliver an ambitious program for the rapid and efficient delivery of Celgene’s portfolio in Oncology, Inflammation, Immunology and Cell Therapies.

Main Purpose of the Role

Translational development at molecular level and mutation analysis

Responsibilities:

Scientific:

• To work with discovery to develop target validation approaches.

• To work with human samples and their molecular signature analysis

• To have good knowledge of molecular biology, somatic mutation analysis, and its application to translational research

• To introduce new technologies as appropriate

• To ensure standards Good Manufacturing/Laboratory Practice and accreditation bodies

• To understand basic cancer research and check and interpret testing results reported

• To advise on and resolve any discrepancies or deviations

• To present analysis of data from laboratories for publication and presentation at scientific and management meetings

• To carry out research in oncology, inflammation, immunology and cell therapies

Managerial:

• To arrange the performance appraisal and regular assessment of laboratory staff

• To ensure the health, safety and welfare of all staff, by ensuring staff comply with Health and Safety regulations

• To represent Celgene in any scientific forums

• To deal with all issues that may arise within the HDTL Labs (with the HR Department)

• To ensure appropriately qualified staff are employed and that staffing levels are commensurate with the work being carried out

• To cooperate with any tissue laboratory from Europe and beyond and external groups collaborating with the clinical and research projects

• To determine appropriate supplies (including testing kits and equipment) to be purchased for use in the laboratories after relevant evaluation procedures performed

Operational:

• To ensure all inventory items are tested

• To ensure all samples have full range of tests applied

• To collaborate with the Research Department for information and material to other centers

• To ensure the correct and timely dispatch of tissue and tumor material centers

This position, Scientist, Molecular Biologist in Seville, was posted on March 21, 2011. The job is located in Seville. The employer is Celgene. Since this job has been published, it has been viewed 246 times.